![]() For example, inhibition of Hedgehog signaling improves delivery and efficacy of gemcitabine in a mouse pancreatic cancer model. Inhibition of cancer stromal interaction may prevent neovascularization, invasion, and metastasis and improve anti-cancer drug delivery. Recently, there has been a growing interest in targeting cancer microenvironment for cancer treatment. ![]() Thus cancer microenvironment is regarded as a key contributor for epithelial-mesenchymal transition of the cancer cells, angiogenesis, cancer progression and metastasis, and development of drug resistance. Conversely, cancer cells promote fibroblast proliferations, immune cell migration and angiogenesis through signal transduction. Stromal cells in cancer microenvironment promote maintenance, growth and progression of cancer cells through the release of humoral factors and direct cell contact. Cancer cells generally survive in microenvironment surrounded by non-cancer “stromal” cells such as endothelial cells, fibroblasts and immune cells. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |